Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes
is a common herbal remedy used to treat a variety of illnesses, though its health benefits and effects on the immune system have not been fully elucidated. In this study, we investigated the effect of root extract on the survival of concanavalin A (ConA)-activated murine splenocytes and the producti...
Saved in:
Published in | Journal of medicinal food Vol. 22; no. 11; p. 1146 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.11.2019
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Summary: | is a common herbal remedy used to treat a variety of illnesses, though its health benefits and effects on the immune system have not been fully elucidated. In this study, we investigated the effect of
root extract on the survival of concanavalin A (ConA)-activated murine splenocytes and the production of the cytokines interferon-gamma (IFN-
), interleukin-2 (IL-2), and tumor necrosis factor (TNF) by these cells. We found that
root extract did not affect splenocyte survival or IL-2 production and increased IFN-
cytokine levels only modestly. However, TNF cytokine production by ConA-activated splenocytes increased in response to
root extract treatment in a dose-dependent manner, suggesting that
root extract does have immunomodulatory effects. |
---|---|
ISSN: | 1557-7600 |
DOI: | 10.1089/jmf.2019.0065 |