DNA damage in Wistar rats exposed to dithiocarbamate pesticide mancozeb

Pesticides are used in large amounts in agriculture and the evaluation of their toxic effects is of major concern to public and environmental health. The aim of the present study was to investigate the genotoxic potential of a commercial formulation of the fungicide mancozeb by the micronucleus test...

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Bibliographic Details
Published inFolia biologica Vol. 60; no. 4; pp. 202 - 204
Main Authors Goldoni, A, Klauck, C R, Da Silva, S T, Da Silva, M D, Ardenghi, P G, Da Silva, L B
Format Journal Article
LanguageEnglish
Published Czech Republic Charles University in Prague, First Faculty of Medicine 01.01.2014
Subjects
Animals
Ditiocarb - toxicity
DNA Damage
Erythrocyte Count
Erythrocytes - drug effects
Erythrocytes - metabolism
Male
Maneb - toxicity
Micronuclei, Chromosome-Defective - drug effects
Micronucleus Tests
Rats, Wistar
Zineb - toxicity
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Summary:Pesticides are used in large amounts in agriculture and the evaluation of their toxic effects is of major concern to public and environmental health. The aim of the present study was to investigate the genotoxic potential of a commercial formulation of the fungicide mancozeb by the micronucleus test in bone marrow and the comet assay in total blood of Wistar rats. Adult male Wistar rats were treated with a solution of mancozeb at a concentration of 40 mg/kg/day, administered intraperitoneally for 18 consecutive days, and compared to a control group. The results indicate that mancozeb induced significantly higher DNA damage as detected by the comet assay and increased the frequency of micronuclei. The results show that mancozeb is genotoxic and may adversely affect the DNA integrity of exposed organisms.
ISSN:0015-5500
2533-7602
DOI:10.14712/fb2014060040202