An efficient solventless synthesis of cycloalkeno-1,2,3-selenadiazoles, their antimicrobial studies, and comparison with parent semicarbazones

• Published in: Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 51; no. 1; pp. 102 - 106
• Main Authors: Jadhav, Aditi A., Dhanwe, Vaishali P., Joshi, Prasad G., Khanna, Pawan K.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 2015; Springer Nature; Springer
• Subjects: Bacteria; Chemistry; Chemistry and Materials Science; Chemistry, Organic; Escherichia coli; Organic Chemistry; Pharmacy; Physical Sciences; Science & Technology; organoselenium compounds; semicarbazones; solventless synthesis; selenadiazoles; grinding; ORGANOSELENIUM; CDSE QUANTUM DOTS
• ISSN: 0009-3122; 1573-8353
• DOI: 10.1007/s10593-015-1666-9

A series of heterocyclic organoselenium compounds, cycloalkeno-1,2,3-selenadiazoles (cyclopenteno, cyclohexeno, cyclohepteno, and cycloocteno-1,2,3-selenadiazoles), was synthesized at room temperature in one step under solventless conditions from the corresponding semicarbazones. The synthesized 1,2,3-selenadiazoles and their parent semicarbazones were screened for their antimicrobial activity against various pathogenic bacteria using agar disc diffusion method. All compounds were found active against E. coli , S. aureus , S. typhi , and P. aeruginosa . Among all the tested selenadiazoles, cyclopenteno-1,2,3-selenadiazole showed excellent inhibition against highly resistant P. aeruginosa . It is observed that selenadiazoles showed higher activity compared with the respective semicarbazones.