Polygalae Radix: review of metabolites, pharmacological activities and toxicology
Polygalae Radix : is the dried root of Polygala tenuifolia Willd. or Polygala sibirica L., which has the effect of improving memory and cognitive function in traditional Chinese medicine. Modern pharmacological studies indicated that Polygalae Radix has rich pharmacological activities in vitro and i...
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Published in | Frontiers in pharmacology Vol. 15; p. 1420853 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
30.05.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Polygalae Radix
: is the dried root of
Polygala tenuifolia
Willd. or
Polygala sibirica
L., which has the effect of improving memory and cognitive function in traditional Chinese medicine. Modern pharmacological studies indicated that
Polygalae Radix
has rich pharmacological activities
in vitro
and
in vivo
, including protective effects on the nervous system, immune system, cardiovascular system and respiratory system, as well as antioxidant and antiepileptic pharmacological activities. Up to now, more than 160 metabolites from
Polygalae Radix
were identified, including triterpenoid saponins, xanthones, oligosaccharide esters and et al. The clinical practice of traditional Chinese medicine has proved that
Polygalae Radix
has a certain irritation to the throat, and a large or long-term use will stimulate the digestive tract, and the main toxic metabolite is saponins. Therefore,
Polygalae Radix
should be pr ocessed or used in combination with other Chinese herbal medicines to reduce the irritation to the throat and reduce gastrointestinal irritation. This article provides a review of the metabolites, pharmacological activity, and toxicology of
Polygalae Radix
. It also discusses the future research prospects and existing problems of
Polygalae Radix
, providing reference for further research on
Polygalae Radix
. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Yuan Feng, Shanxi University of Chinese Medicine, China Bingxin Li, Huaibei Normal University, China Edited by: Gang Chen, Shenyang Pharmaceutical University, China |
ISSN: | 1663-9812 1663-9812 |
DOI: | 10.3389/fphar.2024.1420853 |