Experimental intracerebral mass: time-related effects on local cerebral blood flow

Cerebral blood flow (CBF) was measured at different times during the first 150 minutes following an experimental space-occupying lesion produced with a 50-microliter microballoon in rats. Local CBF was measured with the carbon-14-labeled iodoantipyrine quantitative autoradiographic technique. A regi...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 67; no. 5; p. 732
Main Authors Kingman, T A, Mendelow, A D, Graham, D I, Teasdale, G M
Format Journal Article
LanguageEnglish
Published United States 01.11.1987
Subjects
Animals
Autoradiography
Brain Neoplasms - physiopathology
Cerebrovascular Circulation
Male
Rats
Rats, Inbred Strains
Staining and Labeling
Time Factors
Tissue Distribution
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Summary:Cerebral blood flow (CBF) was measured at different times during the first 150 minutes following an experimental space-occupying lesion produced with a 50-microliter microballoon in rats. Local CBF was measured with the carbon-14-labeled iodoantipyrine quantitative autoradiographic technique. A region of local ischemia developed around the mass, while the remote effects of the mass were minimal. The focal ischemic lesion enlarged with time, and simulated removal of the lesion within this design did not alleviate the ischemia.
ISSN:0022-3085
DOI:10.3171/jns.1987.67.5.0732