Alternative polyadenylation of antisense RNAs and flowering time control

Flowering time is controlled by precision in gene regulation mediated by different pathways. Two Arabidopsis thaliana components of the autonomous flowering pathway, FCA and FPA, function as genetically independent trans-acting regulators of alternative cleavage and polyadenylation. FCA and FPA dire...

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Bibliographic Details
Published inBiochemical Society transactions Vol. 38; no. 4; p. 1077
Main Authors Hornyik, Csaba, Duc, Céline, Rataj, Katarzyna, Terzi, Lionel C, Simpson, Gordon G
Format Journal Article
LanguageEnglish
Published England 01.08.2010
Subjects
Arabidopsis - genetics
Arabidopsis - growth & development
Arabidopsis - metabolism
Flowers - genetics
Flowers - growth & development
Flowers - metabolism
Gene Expression Regulation, Plant
Models, Biological
Polyadenylation - physiology
RNA Splice Sites - physiology
RNA, Antisense - metabolism
Time Factors
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Summary:Flowering time is controlled by precision in gene regulation mediated by different pathways. Two Arabidopsis thaliana components of the autonomous flowering pathway, FCA and FPA, function as genetically independent trans-acting regulators of alternative cleavage and polyadenylation. FCA and FPA directly associate with chromatin at the locus encoding the floral repressor FLC, but appear to control FLC transcription by mediating alternative polyadenylation of embedded non-coding antisense RNAs. These findings prompt the re-examination of how other factors control FLC expression, as it is formally possible that they function primarily to control alternative processing of antisense RNAs. As co-expressed sense and antisense gene pairs are widespread in eukaryotes, alternative processing of antisense RNAs may represent a significant form of gene regulation.
ISSN:1470-8752
DOI:10.1042/BST0381077