N-Functionalised polyfluoropyridazin-3(2 H)-one derivatives

• Published in: Tetrahedron Vol. 65; no. 43; pp. 8844 - 8850
• Main Authors: Pattison, Graham, Sandford, Graham, Yufit, Dmitry S., Howard, Judith A.K., Christopher, John A., Miller, David D.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 24.10.2009; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Exact sciences and technology; Heterocyclic compounds; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; Organic chemistry; Physical Sciences; Preparations and properties; Science & Technology; NUCLEOPHILIC-SUBSTITUTION; SCAFFOLDS; Biological properties; Nucleophilic reaction; Polyfunctional compound; Nitrogen heterocycle; Biological activity; Chemical substitution; Functionalization; Analog; Pyridazine derivatives; Aromatic compound; Fluorine Organic compounds; Nucleophilic substitution; Chemical synthesis; Protection
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2009.08.050

Pyridazin-3(2 H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but, in general, synthesis of polysubstituted analogues can be very difficult to achieve. An approach to the syntheses of polyfunctional pyridazinone systems involving sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2 H)-ones as the core scaffolds is described. [Display omitted]