The synthesis of 12-membered macrocycles containing a C1–C8 alkene unit via ring-closing metathesis
Model cross and ring-closing metathesis strategies toward the C1–C8-linear carbon skeleton are presented. The introduction of a four-atom tether enables the formation of 12-membered rings in good-to-excellent yields and stereoselectivity. Furthermore, the study revealed that the cross-metathesis app...
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Published in | Tetrahedron Vol. 68; no. 25; pp. 5081 - 5086 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
24.06.2012
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Model cross and ring-closing metathesis strategies toward the C1–C8-linear carbon skeleton are presented. The introduction of a four-atom tether enables the formation of 12-membered rings in good-to-excellent yields and stereoselectivity. Furthermore, the study revealed that the cross-metathesis approach and the formation of medium ring sizes via ring-closing metathesis are much less favorable.
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ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2012.04.043 |