High-Polyphenol Sorghum Bran Extract Inhibits Cancer Cell Growth Through ROS Induction, Cell Cycle Arrest, and Apoptosis

As diet is one of the major controllable factors in cancer development, potentially chemopreventive foods are of significant interest to public health. One such food is sorghum (Sorghum bicolor), a cereal grain that contains varying concentrations of polyphenols. In a panel of 15 sorghum germplasm,...

Full description

Saved in:
Bibliographic Details
Published inJournal of medicinal food Vol. 21; no. 10; p. 990
Main Authors Smolensky, Dmitriy, Rhodes, Davina, McVey, D Scott, Fawver, Zachary, Perumal, Ramasamy, Herald, Thomas, Noronha, Leela
Format Journal Article
LanguageEnglish
Published United States 01.10.2018
Subjects
Apoptosis - drug effects
Caco-2 Cells
Cell Cycle Checkpoints - drug effects
Cell Proliferation - drug effects
DNA Damage - drug effects
Hep G2 Cells
Humans
Neoplasms - metabolism
Neoplasms - physiopathology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Polyphenols - chemistry
Polyphenols - pharmacology
Reactive Oxygen Species - metabolism
Seeds - chemistry
Sorghum - chemistry
polyphenols
apoptosis
sorghum
cancer
cell cycle
reactive oxygen species
Online AccessGet more information

Cover

More Information
Summary:As diet is one of the major controllable factors in cancer development, potentially chemopreventive foods are of significant interest to public health. One such food is sorghum (Sorghum bicolor), a cereal grain that contains varying concentrations of polyphenols. In a panel of 15 sorghum germplasm, we identified strains with higher polyphenol content than previously reported for this grain. Bran extracts from the germplasm with the highest and lowest polyphenol content were then tested against HepG2 and Caco2 cancer cells to assess effects on cancer cell viability, reactive oxygen species, apoptosis, DNA damage, cell cycle arrest, and protein expression patterns. High-polyphenol extracts, but not low-polyphenol extracts, reduced cell viability by inducing apoptosis and cell cycle arrest following production of reactive oxygen species and oxidative DNA damage. The results indicate that high-polyphenol sorghum bran extracts have potential anticancer properties and warrant further research, not only to test against specific cancers but also to elucidate underlying mechanisms of action.
ISSN:1557-7600
DOI:10.1089/jmf.2018.0008