Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4

• Published in: Tetrahedron Vol. 67; no. 37; pp. 7085 - 7089
• Main Authors: Zhuang, Yibin, Teng, Xiancun, Wang, Yi, Liu, Peipei, Wang, Hui, Li, Jing, Li, Guoqiang, Zhu, Weiming
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 16.09.2011; Elsevier
• Subjects: Aspergillus versicolor; Chemistry; Chemistry, Organic; Cladiella sp; Coral-associated fungus; Cyclopentapeptides; Exact sciences and technology; Organic chemistry; Peptides; Physical Sciences; Polyketides; Preparations and properties; Science & Technology; Polyketides; Cyclopentapeptides; Aspergillus versicolor; Coral-associated fungus; Cladiella sp; GONIOBUTENOLIDE-A; Peptides; Cyclic peptides; Animal origin; Fungi; Marine environment; Polyketide; Coelenterata; Coral; Cnidaria; Fungi Imperfecti; Invertebrata; Pentapeptide
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2011.07.003

Three new cyclopentapeptides, versicoloritides A–C ( 1– 3), a new orcinol tetramer, tetraorcinol A ( 4), and two new lactones, versicolactones A and B ( 5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1– 4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter a erogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC 50 value of 67 μM. [Display omitted]