Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

The synthesis of a new series of 1β-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compoun...

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Published inBulletin of the Korean Chemical Society Vol. 29; no. 8; pp. 1472 - 1478
Main Authors 오창현, Hyeong Beom Park, Myung Ho Jung, Jung-Hyuck Cho
Format Journal Article
LanguageEnglish
Published 대한화학회 20.08.2008
Subjects
화학
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Summary:The synthesis of a new series of 1β-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5- azaspiro[2,4]heptane moiety showed the most potent antibacterial activity. KCI Citation Count: 0
Bibliography:G704-000067.2008.29.8.044
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2008.29.8.1472