Binding patterns of five monoclonal antibodies to Actinobacillus (Haemophilus) pleuropneumoniae

Five monoclonal antibodies were obtained after immunising mice with superficial antigens of three strains representing serovars 1 to 3 of Actinobacillus (Haemophilus) pleuro-pneumoniae. When tested in ELISA against the standard strains representing serovars 1 to 10, the monoclonal antibody raised ag...

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Bibliographic Details
Published inResearch in veterinary science Vol. 43; no. 3; pp. 410 - 412
Main Authors Lida, J, Smith, I.M
Format Journal Article
LanguageEnglish
Published England 01.11.1987
Subjects
Actinobacillus - immunology
Actinobacillus pleuropneumoniae
Antibodies, Monoclonal - immunology
Antigen-Antibody Reactions
Antigens, Bacterial - immunology
binding
Enzyme-Linked Immunosorbent Assay
genetic variation
In Vitro Techniques
mice
monoclonal antibodies
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Summary:Five monoclonal antibodies were obtained after immunising mice with superficial antigens of three strains representing serovars 1 to 3 of Actinobacillus (Haemophilus) pleuro-pneumoniae. When tested in ELISA against the standard strains representing serovars 1 to 10, the monoclonal antibody raised against the standard strain of serovar 1 reacted only with that strain. Of the three monoclonal antibodies raised against the standard strain of serovar 3, one reacted with serovars 3 and 8 only, another with serovar 7 only and the third with the strains representing serovars 7, 9 and 10. The monoclonal antibodies produced with the serovar 2 strain also reacted with a wide spectrum of strains, representing serovars 7 to 10.
ISSN:0034-5288
1532-2661
DOI:10.1016/S0034-5288(18)30816-6