Autoantibodies against a kidney--liver protein associated with quinolone-induced acute interstitial nephritis or hepatitis
In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera from these patients contained autoantibodies that recognize a 65-kDa protein expressed in normal human kidney and liver...
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Published in | Nephrology, dialysis, transplantation Vol. 12; no. 9; pp. 1961 - 1962 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.09.1997
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Subjects | |
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Abstract | In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera from these patients contained autoantibodies that recognize a 65-kDa protein expressed in normal human kidney and liver microsomes. Only 6% of sera from healthy individuals who did not ingest quinolone recognized the same protein. These findings suggest that the presence of autoantibodies could be used as a sensitive marker and that a modification of microsomal proteins by quinolone itself or by a metabolite could generated an autoimmune response. |
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AbstractList | In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera from these patients contained autoantibodies that recognize a 65-kDa protein expressed in normal human kidney and liver microsomes. Only 6% of sera from healthy individuals who did not ingest quinolone recognized the same protein. These findings suggest that the presence of autoantibodies could be used as a sensitive marker and that a modification of microsomal proteins by quinolone itself or by a metabolite could generated an autoimmune response. |
Author | Fillastre, J P Mircheva, J Druet, P Simon, P Glotz, D Gauffre, A Beaune, P H |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9306350$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Acute Disease Anti-Bacterial Agents - adverse effects Autoantibodies - analysis Autoantibodies - immunology Biomarkers Chemical and Drug Induced Liver Injury - immunology Humans Immunoblotting Kidney - metabolism Liver - metabolism Microsomes - metabolism Nephritis, Interstitial - chemically induced Nephritis, Interstitial - immunology Proteins - immunology Proteins - metabolism Quinolones - adverse effects |
Title | Autoantibodies against a kidney--liver protein associated with quinolone-induced acute interstitial nephritis or hepatitis |
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