Autoantibodies against a kidney--liver protein associated with quinolone-induced acute interstitial nephritis or hepatitis

In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera from these patients contained autoantibodies that recognize a 65-kDa protein expressed in normal human kidney and liver...

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Published inNephrology, dialysis, transplantation Vol. 12; no. 9; pp. 1961 - 1962
Main Authors Gauffre, A, Mircheva, J, Glotz, D, Fillastre, J P, Simon, P, Beaune, P H, Druet, P
Format Journal Article
LanguageEnglish
Published England 01.09.1997
Subjects
Acute Disease
Anti-Bacterial Agents - adverse effects
Autoantibodies - analysis
Autoantibodies - immunology
Biomarkers
Chemical and Drug Induced Liver Injury - immunology
Humans
Immunoblotting
Kidney - metabolism
Liver - metabolism
Microsomes - metabolism
Nephritis, Interstitial - chemically induced
Nephritis, Interstitial - immunology
Proteins - immunology
Proteins - metabolism
Quinolones - adverse effects
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Summary:In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera from these patients contained autoantibodies that recognize a 65-kDa protein expressed in normal human kidney and liver microsomes. Only 6% of sera from healthy individuals who did not ingest quinolone recognized the same protein. These findings suggest that the presence of autoantibodies could be used as a sensitive marker and that a modification of microsomal proteins by quinolone itself or by a metabolite could generated an autoimmune response.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/12.9.1961