Niruriflavone, a New Antioxidant Flavone Sulfonic Acid from Phyllanthus niruri

A new flavone sulfonic acid 1 named niruriflavone was isolated from the 70% ethanolic extract of the whole plant of Phyllanthus niruri (Euphorbiaceae), together with 6,10,14-trimethyl-2- pentadecanone, hypophyllanthin, gallic acid, brevifolin carboxylic acid, methyl brevifolin carboxylate, isoquerce...

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Published inZeitschrift für Naturforschung. B, A journal of chemical sciences Vol. 61; no. 1; pp. 57 - 60
Main Authors Than, N. N., Fotso, S., Poeggeler, B., Hardeland, R., Laatsch, H.
Format Journal Article
LanguageEnglish
Published BERLIN Verlag der Zeitschrift für Naturforschung 01.01.2006
Walter De Gruyter
Subjects
Antioxidant Activity
Bioluminescent Dinoflagellates
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Niruriflavone
Phyllanthus niruri
Physical Sciences
Science & Technology
Toxicity
Phyllanthus niruri
toxicity
bioluminescent dinoflagellates
TANNINS
niruriflavone
antioxidant activity
MEDICINAL-PLANTS
CONSTITUENTS
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Summary:A new flavone sulfonic acid 1 named niruriflavone was isolated from the 70% ethanolic extract of the whole plant of Phyllanthus niruri (Euphorbiaceae), together with 6,10,14-trimethyl-2- pentadecanone, hypophyllanthin, gallic acid, brevifolin carboxylic acid, methyl brevifolin carboxylate, isoquercetin, quercetin-3-O-β -D-glucopyranosyl(1→ 4)-α-rhamnopyranoside, corilagin, and isocorilagin, whose structures were determined by spectroscopic methods and comparison with published data. In an ABTS cation radical reduction assay, niruriflavone (1) exhibited potent radical scavenging properties. A biological test system based on bioluminescence of the dinoflagellate Lingulodinium polyedrum did not reveal any prooxidant properties of 1 at 50 μM.
ISSN:0932-0776
1865-7117
DOI:10.1515/znb-2006-0111