An Effective Activation of Palladium Phosphine Complexes in Aqueous Phase Reactions of Hetero-Aromatic Boronic Acids with Aryl Halides

We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h -1 ) by selecting an aqueous reaction medium instead of organic solvents. This method was elaborated for a high yield synthesis of heteroaroma...

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 50; no. 1; pp. 19 - 25
Main Authors Bumagin, N. A., Veselov, I. S., Belov, D. S.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.04.2014
Springer
Subjects
Chemical tests and reagents
Chemistry
Chemistry and Materials Science
Halides
Organic Chemistry
Palladium
Pharmacy
Substitution reactions
palladium phosphine complexes
activation
water
heteroaromatic boronic acids
Suzuki reaction
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Summary:We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h -1 ) by selecting an aqueous reaction medium instead of organic solvents. This method was elaborated for a high yield synthesis of heteroaromatic biaryls with furyl and thienyl groups.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1443-1