Localized muscular mucormycosis in a child with acute leukemia

• Published in: Japanese journal of clinical oncology Vol. 27; no. 5; pp. 357 - 360
• Main Authors: Kang, C M, Kim, H S, Song, K S, Lee, H J, Kwon, K Y
• Format: Journal Article
• Language: English
• Published: England 01.10.1997
• Subjects: Acute Disease; Amphotericin B - therapeutic use; Antifungal Agents - therapeutic use; Child; Combined Modality Therapy; Debridement; Humans; Leukemia - complications; Male; Mucormycosis - drug therapy; Mucormycosis - etiology; Mucormycosis - surgery; Muscular Diseases - drug therapy; Muscular Diseases - etiology; Muscular Diseases - surgery
• ISSN: 0368-2811; 1465-3621
• DOI: 10.1093/jjco/27.5.357

Mucormycosis is a rare fungal infection of childhood, occurring mainly in patients with chronic illnesses such as diabetes and malignancies. The fungus seldom grows in culture and confirmation of the diagnosis depends on histologic examination of infected tissues. To date, the reported natural history of the disease has been rapid progression and a fatal outcome. Therefore, the importance of early diagnosis by tissue biopsy and early treatment with surgical debridement and systemic antifungal therapy cannot be overemphasized. The pulmonary system is the most common site for mucormycosis in patients with leukemia. We report what we believe to be the first successfully treated case of isolated muscular mucormycosis occurring in a child with biphenotypic acute leukemia. The diagnosis was made promptly by tissue examination at the time of surgical debridement. The patient was also given systemic amphotericin-B therapy.