Fluorescent Probes for Analysis and Imaging of Monoamine Oxidase Activity

Monoamine oxidases catalyze the oxidative deamination of dietary amines and amine neurotransmitters, and assist in maintaining the homeostasis of the amine neurotransmitters in the brain. Dysfunctions of these enzymes can cause neurological and behavioral disorders including Parkinson’s and Alzheime...

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Published inBulletin of the Korean Chemical Society Vol. 35; no. 5; pp. 1269 - 1274
Main Authors Kim, Dokyoung, Jun, Yong Woong, Ahn, Kyo Han
Format Journal Article
LanguageEnglish
Published 대한화학회 20.05.2014
Subjects
화학
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Summary:Monoamine oxidases catalyze the oxidative deamination of dietary amines and amine neurotransmitters, and assist in maintaining the homeostasis of the amine neurotransmitters in the brain. Dysfunctions of these enzymes can cause neurological and behavioral disorders including Parkinson’s and Alzheimer’s diseases. To understand their physiological roles, efficient assay methods for monoamine oxidases are essential. Reviewed in this Perspective are the recent progress in the development of fluorescent probes for monoamine oxidases and their applications to enzyme assays in cells and tissues. It is evident that still there is strong need for a fluorescent probe with desirable substrate selectivity and photophysical properties to challenge the much unsolved issues associated with the enzymes and the diseases. KCI Citation Count: 4
Bibliography:http://journal.kcsnet.or.kr/main/j_search/j_abstract_view.htm?code=B140501&qpage=j_search&spage=b_bkcs&dpage=ar
G704-000067.2014.35.5.049
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2014.35.5.1269