Polyprenylated Xanthones and Benzophenones from the Bark of Garcinia oblongifolia

A new polyprenylated xanthone (=9H‐xanthen‐9‐one) and a new polyprenylated benzophenone, namely oblongifolixanthone A (1) and garciniagifolone A (2), were isolated from the bark of Garcinia oblongifolia, together with five known compounds including the four xanthones 3–5 and 7 and a benzophenone 6....

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Published inHelvetica chimica acta Vol. 95; no. 8; pp. 1442 - 1448
Main Authors Shan, Wei-Guang, Lin, Tian-Song, Yu, Hai-Ning, Chen, Yan, Zhan, Zha-Jun
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.08.2012
WILEY‐VCH Verlag
Wiley
Subjects
Chemistry
Chemistry, Multidisciplinary
Cytotoxic activity
Garcinia oblongifolia
Garciniagifolone A
Oblongifolixanthone A
Physical Sciences
Science & Technology
Garciniagifolone A
CELLS
Oblongifolixanthone A
ACYLPHLOROGLUCINOLS
MANGOSTANA
PRENYLATED XANTHONES
DERIVATIVES
Garcinia oblongifolia
Cytotoxic activity
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Summary:A new polyprenylated xanthone (=9H‐xanthen‐9‐one) and a new polyprenylated benzophenone, namely oblongifolixanthone A (1) and garciniagifolone A (2), were isolated from the bark of Garcinia oblongifolia, together with five known compounds including the four xanthones 3–5 and 7 and a benzophenone 6. The structures of 1 and 2 were established by detailed analysis of their spectroscopic data, especially 1D‐ and 2D‐NMR spectra and HR‐ESI‐MS data. All these compounds were assayed for their cytotoxic activities against three human tumor cell lines (HeLa, SGC7901, and HepG2). The 1,3,6,7‐tetrahydroxy‐9H‐xanthen‐9‐one (3) was inactive, and the other compounds showed weak to moderate activity.
Bibliography:ark:/67375/WNG-7K79D8X5-2
istex:A1B65C0803EA927A429434443D604811B6D8AEBB
ArticleID:HLCA201200019
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201200019