P2X7 receptors in cerebral ischemia

Cerebral ischemia is one of the most common diseases resulting in death and disability in aged people. It leads immediately to rapid energy failure, ATP depletion, and ionic imbalance, which increase extracellular ATP levels and accordingly activate P2X7 receptors. These receptors are ATP-gated cati...

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Bibliographic Details
Published inNeuroscience bulletin Vol. 29; no. 3; pp. 390 - 398
Main Authors Bai, Hui-Yu, Li, Ai-Ping
Format Journal Article
LanguageEnglish
Published Heidelberg Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 01.06.2013
Subjects
Anatomy
Anesthesiology
ATP水平
Biomedical and Life Sciences
Biomedicine
Human Physiology
Neurology
Neurosciences
P2X7
Pain Medicine
Review
免疫活性细胞
受体拮抗剂
神经细胞
离子通道
缺血性脑损伤
脑缺血
receptor
neurotoxicity
neuroinflammation
cerebral ischemia
P2X
calcium overload
neurotransmitter
receptor antagonist
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Summary:Cerebral ischemia is one of the most common diseases resulting in death and disability in aged people. It leads immediately to rapid energy failure, ATP depletion, and ionic imbalance, which increase extracellular ATP levels and accordingly activate P2X7 receptors. These receptors are ATP-gated cation channels and widely distributed in nerve cells, especially in the immunocompetent cells of the brain. Currently, interest in the roles of P2Xz receptors in ischemic brain injury is growing. In this review, we discuss recent research progress on the actions of P2X7 receptors, their possible mechanisms in cerebral ischemia, and the potential therapeutic value of P2X7 receptor antagonists which may provide a new target both for clinical and for research purposes.
Bibliography:P2X7 receptor; cerebral ischemia; neurotoxicity; calcium overload; neuroinflammation; neurotrans-mitter; receptor antagonist
31-1975/R
Cerebral ischemia is one of the most common diseases resulting in death and disability in aged people. It leads immediately to rapid energy failure, ATP depletion, and ionic imbalance, which increase extracellular ATP levels and accordingly activate P2X7 receptors. These receptors are ATP-gated cation channels and widely distributed in nerve cells, especially in the immunocompetent cells of the brain. Currently, interest in the roles of P2Xz receptors in ischemic brain injury is growing. In this review, we discuss recent research progress on the actions of P2X7 receptors, their possible mechanisms in cerebral ischemia, and the potential therapeutic value of P2X7 receptor antagonists which may provide a new target both for clinical and for research purposes.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-013-1338-7