DNA Interactions Mediated by Cyclopentadienidoruthenium(II) Complexes Containing Water-Soluble Phosphanes
The water‐soluble ruthenium(II) complexes Na2[RuCpX(mTPPMS)2] [X = Cl (1), I (2)] and Nax[RuCp(mTPPMS)(PR13)(PR23)](OTf)y [PR13 = PR23 = PPh3 (3), PTA (4), x = y = 0; PR13 = mTPPMS, PR23 = PTA (5), x = 1, y = 0; PR13 = mTPPMS, PR23 = mPTA (6), x = y = 0; PR13 = PR23 = mTPPMS (7), x = 2, y = 0; PR13...
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Published in | European Journal of Inorganic Chemistry Vol. 2007; no. 18; pp. 2803 - 2812 |
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Main Authors | , , , , , , , |
Format | Book Review Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.06.2007
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | The water‐soluble ruthenium(II) complexes Na2[RuCpX(mTPPMS)2] [X = Cl (1), I (2)] and Nax[RuCp(mTPPMS)(PR13)(PR23)](OTf)y [PR13 = PR23 = PPh3 (3), PTA (4), x = y = 0; PR13 = mTPPMS, PR23 = PTA (5), x = 1, y = 0; PR13 = mTPPMS, PR23 = mPTA (6), x = y = 0; PR13 = PR23 = mTPPMS (7), x = 2, y = 0; PR13 = PPh3, PR23 = PTA (8), x = y = 0; PR13 = mPTA, PR23 = PPh3 (9), x = 0, y = 1; mTPPMS = Ph2P(3‐OSO2C6H4)–; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; mPTA = N‐methyl‐1,3,5‐triaza‐7‐phosphaadamantane] have been synthesized and characterised by elemental analysis, NMR and IR spectroscopy and crystallographic methods. The X‐ray crystal structure determination of [RuCp(mTPPMS)(PPh3)(PTA)]·2H2O (8·2H2O), which is the first half‐sandwich ruthenium complex bearing three different phosphanes, has also been determined. The binding properties of these new water‐soluble ruthenium complexes towards DNA and the interaction of free mTPPMS with the nucleic acid have been studied using the mobility shift assay, which has shown that both the activity of the ruthenium complexes and the possible mechanism governing the interaction with DNA are strictly dependent on the composition of the complexes.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) |
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Bibliography: | Ministerio de Asuntos Exteriores y de Cooperación - Agencia Española de Cooperación Internacional (MAE-AECI) Ministerio de Ciencia y Tecnología (MCYT) - No. CTQ2006-06552/BQU.MCRTN; No. MRTN-CT-2003-503864 ArticleID:EJIC200601177 Junta de Andalucía - No. FQM-317,; No. AM 55/04; No. AM 56/04 European Cooperation in the Field of Science and Technology (COST) istex:9B01D9BF099F88250AC72CAF3034B5B7772D01DE Centro Nazionale di Ricerca ark:/67375/WNG-VW0XGFZZ-M |
ISSN: | 1434-1948 1099-0682 |
DOI: | 10.1002/ejic.200601177 |