Emerging off‐label esthetic uses of botulinum toxin in dermatology

Botulinum toxin is a neurotoxic protein produced by Clostridium botulinum, the bacterium responsible for botulism. Botulinum toxin was first used for therapeutic indications in the 1970s for the treatment of strabismus. With greater understanding of its underlying physiology and safety profile, the...

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Bibliographic Details
Published inDermatologic therapy Vol. 35; no. 1; pp. e15205 - n/a
Main Authors Phan, Kevin, Younessi, Shannon, Dubin, Danielle, Lin, Matthew J., Khorasani, Hooman
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.01.2022
Subjects
botox
botulinum toxin
Botulinum Toxins, Type A - therapeutic use
cosmetic
Dermatology
esthetic
Esthetics
Humans
Off-Label Use
off‐label
botulinum toxin
botox
cosmetic
esthetic
off-label
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Summary:Botulinum toxin is a neurotoxic protein produced by Clostridium botulinum, the bacterium responsible for botulism. Botulinum toxin was first used for therapeutic indications in the 1970s for the treatment of strabismus. With greater understanding of its underlying physiology and safety profile, the use of botulinum toxin has now expanded to a range of cosmetic and medical indications. We performed a systematic review of current literature on the applications of botulinum toxin on off‐label esthetic uses. Electronic databases were searched for original published studies including randomized trials, observational or cohort studies, as well as relevant case reports. To add to the body of evidence, our review summarizes and synthesizes key study characteristics, results, and level of evidence for each use case. Although the body of evidence remains weak, there is increasing support for the use of botulinum toxin in emerging off‐label esthetic uses of botulinum toxin in dermatology.
ISSN:1396-0296
1529-8019
DOI:10.1111/dth.15205