Synthesis and Biological Activity of 4,5-Dihydro-1,2,4-triazole-5-thione Schiff Base
The 4,5‐dihydro‐1,2,4‐triazole Schiff base derivatives were synthesized with 4‐amino‐4,5‐dihydro‐3‐(phenoxy‐ methyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the compounds have been confirmed by 1H NMR, IR spectra and elemental analysis. Their biological a...
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| Published in | Chinese journal of chemistry Vol. 27; no. 7; pp. 1397 - 1400 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
WILEY-VCH Verlag
01.07.2009
WILEY‐VCH Verlag Wiley |
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| Abstract | The 4,5‐dihydro‐1,2,4‐triazole Schiff base derivatives were synthesized with 4‐amino‐4,5‐dihydro‐3‐(phenoxy‐ methyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the compounds have been confirmed by 1H NMR, IR spectra and elemental analysis. Their biological activities were investigated, and the results showed that they exhibited good fungicidal activities.
4,5‐Dihydro‐1,2,4‐triazole‐5‐thione Schiff base derivatives were synthesized by 4‐amino‐4,5‐dihydro‐3‐(phenoxymethyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the Schiff bases have been confirmed by 1H NMR, IR spectra and elemental analysis. The biological activities of all the Schiff base compounds were investigated. The results showed that they exhibited good fungicidal activities. |
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| AbstractList | Abstract
The 4,5‐dihydro‐1,2,4‐triazole Schiff base derivatives were synthesized with 4‐amino‐4,5‐dihydro‐3‐(phenoxy‐ methyl)‐1
H
‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the compounds have been confirmed by
1
H NMR, IR spectra and elemental analysis. Their biological activities were investigated, and the results showed that they exhibited good fungicidal activities. The 4,5‐dihydro‐1,2,4‐triazole Schiff base derivatives were synthesized with 4‐amino‐4,5‐dihydro‐3‐(phenoxy‐ methyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the compounds have been confirmed by 1H NMR, IR spectra and elemental analysis. Their biological activities were investigated, and the results showed that they exhibited good fungicidal activities. 4,5‐Dihydro‐1,2,4‐triazole‐5‐thione Schiff base derivatives were synthesized by 4‐amino‐4,5‐dihydro‐3‐(phenoxymethyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the Schiff bases have been confirmed by 1H NMR, IR spectra and elemental analysis. The biological activities of all the Schiff base compounds were investigated. The results showed that they exhibited good fungicidal activities. The 4,5-dihydro-1,2,4-triazole Schiff base derivatives were synthesized with 4-amino-4,5-dihydro-3-(phenoxymethyl)-1H-1,2,4-triazole-5-thione and substituted benzaldehydes. The chemical structures of the compounds have been confirmed by H-1 NMR, IR spectra and elemental analysis. Their biological activities were investigated, and the results showed that they exhibited good fungicidal activities. |
| Author | BAI, Yan LIU, Yuanfa SUN, Xiaohong CHEN, Bang JIA, Yingqi ZENG, Zhenfang |
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| Cites_doi | 10.1002/jctb.280510406 10.1002/cjoc.200790290 |
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| Copyright | Copyright © 2009 SIOC, CAS, Shanghai & WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim |
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| References_xml | – volume: 14 start-page: 63 year: 2004 publication-title: Indian J. Heterocycl. Chem. – volume: 9 start-page: 59 year: 1999 publication-title: Indian J. Heterocycl. Chem. – volume: 24 start-page: 506 year: 2004 publication-title: Chin. J. Org. Chem. – volume: 28 start-page: 155 year: 2008 publication-title: Chin. J. Org. Chem. – volume: 25 start-page: 1573 year: 2007 publication-title: Chin. J. Chem. – volume: 51 start-page: 483 year: 1991 publication-title: J. Chem. Technol. Biotechnol. – start-page: 286 year: 1992 – volume: 4 start-page: 117 year: 1990 publication-title: Alex. J. Pharm. Sci. – volume: 23 start-page: 344 year: 2001 publication-title: Chem. Reag. – volume: 19 start-page: 1617 year: 1998 publication-title: Chem. J. Chin. Univ. – volume: 28 start-page: 155 year: 2008 ident: WOS:000252837900028 article-title: Synthesis and biological activities of N-(5-alkyl-2,4-dihydro-3-thioxo-1,2,4-triazol-4-yl) Schiff bases publication-title: CHINESE JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: Sun, XH – volume: 14 start-page: 63 year: 2004 ident: WOS:000224414700017 article-title: Synthesis and antibacterial activity of some new Mannich bases publication-title: INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY contributor: fullname: Holla, BS – volume: 19 start-page: 1617 year: 1998 ident: WOS:000078261500022 article-title: A facile method for the synthesis of 4-amino-5-hydrocarbon-2,4-dihydro-3H-1,2,4-triazole-3-thione Schiff bases publication-title: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE contributor: fullname: Wu, TX – volume: 4 start-page: 117 year: 1990 ident: WOS:000268625200032.2 publication-title: J PHARM SCI contributor: fullname: ELFEKY SAH – volume: 51 start-page: 483 year: 1991 ident: WOS:A1991FR40700005 article-title: SYNTHESIS AND APPLICATION OF SOME NEW HETEROCYCLO-S-TRIAZOLE DERIVATIVES AS ANTIMICROBIAL AGENTS publication-title: JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY contributor: fullname: AWAD, IMA – volume: 23 start-page: 344 year: 2001 ident: WOS:000268625200032.5 publication-title: CHEM REAG contributor: fullname: LIU CY – volume: 24 start-page: 506 year: 2004 ident: WOS:000221269700007 article-title: Synthesis of new fungicide pyrimethanil salts publication-title: CHINESE JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: Sun, XH – start-page: 286 year: 1992 ident: WOS:000268625200032.10 publication-title: GUIDE PREVENTION CUR contributor: fullname: ZHANG X – volume: 9 start-page: 59 year: 1999 ident: WOS:000083044800013 article-title: Synthesis of 1-aminomethyl-3-aryloxymethyl-4-(arylidene)amino-1,2,4-triazole-5-thiones publication-title: INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY contributor: fullname: Holla, BS – volume: 25 start-page: 1573 year: 2007 ident: WOS:000250356900032 article-title: Synthesis and biological activities of substituted triazolethione Schiff base publication-title: CHINESE JOURNAL OF CHEMISTRY contributor: fullname: Sun, XH – volume: 9 start-page: 59 year: 1999 ident: e_1_2_1_5_2 publication-title: Indian J. Heterocycl. Chem. contributor: fullname: Holla B. S. – start-page: 286 volume-title: Guide of Prevention and Cure of the Plant Diseases and Insect Pests in Crop in the Northwest Area year: 1992 ident: e_1_2_1_11_2 contributor: fullname: Zhang X. – volume: 24 start-page: 506 year: 2004 ident: e_1_2_1_10_2 publication-title: Chin. J. Org. Chem. contributor: fullname: Sun X. H. – volume: 19 start-page: 1617 year: 1998 ident: e_1_2_1_7_2 publication-title: Chem. J. Chin. Univ. contributor: fullname: Wu T. X. – volume: 28 start-page: 155 year: 2008 ident: e_1_2_1_8_2 publication-title: Chin. J. Org. Chem. contributor: fullname: Sun X. H. – volume: 23 start-page: 344 year: 2001 ident: e_1_2_1_6_2 publication-title: Chem. Reag. contributor: fullname: Liu C. Y. – volume: 14 start-page: 63 year: 2004 ident: e_1_2_1_4_2 publication-title: Indian J. Heterocycl. Chem. contributor: fullname: Holla B. S. – ident: e_1_2_1_2_2 doi: 10.1002/jctb.280510406 – volume: 4 start-page: 117 year: 1990 ident: e_1_2_1_3_2 publication-title: Alex. J. Pharm. Sci. contributor: fullname: El‐Feky S. A. H. – ident: e_1_2_1_9_2 doi: 10.1002/cjoc.200790290 |
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| Snippet | The 4,5‐dihydro‐1,2,4‐triazole Schiff base derivatives were synthesized with 4‐amino‐4,5‐dihydro‐3‐(phenoxy‐ methyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted... The 4,5-dihydro-1,2,4-triazole Schiff base derivatives were synthesized with 4-amino-4,5-dihydro-3-(phenoxymethyl)-1H-1,2,4-triazole-5-thione and substituted... Abstract The 4,5‐dihydro‐1,2,4‐triazole Schiff base derivatives were synthesized with 4‐amino‐4,5‐dihydro‐3‐(phenoxy‐ methyl)‐1 H ‐1,2,4‐triazole‐5‐thione and... |
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| SubjectTerms | biological activity Chemistry Chemistry, Multidisciplinary Physical Sciences Schiff base Science & Technology synthesis triazole |
| Title | Synthesis and Biological Activity of 4,5-Dihydro-1,2,4-triazole-5-thione Schiff Base |
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