Synthesis and Biological Activity of 4,5-Dihydro-1,2,4-triazole-5-thione Schiff Base

• Published in: Chinese journal of chemistry Vol. 27; no. 7; pp. 1397 - 1400
• Main Authors: SUN, Xiaohong, BAI, Yan, LIU, Yuanfa, CHEN, Bang, JIA, Yingqi, ZENG, Zhenfang
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.07.2009; WILEY‐VCH Verlag; Wiley
• Subjects: biological activity; Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Schiff base; Science & Technology; synthesis; triazole; Schiff base; synthesis; biological activity; triazole
• ISSN: 1001-604X; 1614-7065
• DOI: 10.1002/cjoc.200990234

The 4,5‐dihydro‐1,2,4‐triazole Schiff base derivatives were synthesized with 4‐amino‐4,5‐dihydro‐3‐(phenoxy‐ methyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the compounds have been confirmed by 1H NMR, IR spectra and elemental analysis. Their biological activities were investigated, and the results showed that they exhibited good fungicidal activities. 4,5‐Dihydro‐1,2,4‐triazole‐5‐thione Schiff base derivatives were synthesized by 4‐amino‐4,5‐dihydro‐3‐(phenoxymethyl)‐1H‐1,2,4‐triazole‐5‐thione and substituted benzaldehydes. The chemical structures of the Schiff bases have been confirmed by 1H NMR, IR spectra and elemental analysis. The biological activities of all the Schiff base compounds were investigated. The results showed that they exhibited good fungicidal activities.