Calretinin expression as a critical component in the control of dentate gyrus long-term potentiation induction in mice
We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415). Here, we investigated dentate LTP induction in mice heterozy...
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Published in | The European journal of neuroscience Vol. 10; no. 9; pp. 3029 - 3033 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.09.1998
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Subjects | |
Online Access | Get full text |
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Summary: | We have recently reported that mice homozygous (Cr–/–) for a null mutation in the calretinin gene have impaired long‐term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415). Here, we investigated dentate LTP induction in mice heterozygous (Cr+/–) for the same mutation. Despite the presence of calretinin in neurons of these mice, although at reduced levels as compared with normal mice, LTP induction in dentate gyrus was totally impaired. Spatial memory and learning were found unaffected in Cr+/– mice, such as in Cr–/– mice. Altogether, our results suggest that calretinin is a critical component in the control of dentate synaptic plasticity in mice, and that levels of calretinin higher than those observed in Cr+/– mice are required to induce LTP in this area. The possible mechanisms leading to the absence of correlation between gene dosage and biological effects are discussed. |
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Bibliography: | ark:/67375/WNG-PLS4TK3V-C ArticleID:EJN373 istex:D0B4D5DE7FDCC9013E26AF7CC362FA255708DACC H. Gurden, Laboratoire de Neurobiologie de la Mémoire et de l'Apprentissage, CNRS URA 1491, Building 446, Université Paris‐Sud, 91405 Orsay, France. M. Lemaire, I.T.E.M.‐LABO, 93 Av. De Fontainebleau, 94276 Le Kremlin‐Bicêtre Cedex, France. Present address ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0953-816X 1460-9568 |
DOI: | 10.1111/j.1460-9568.1998.00373.x |