Association between delayed recall and T2 relaxation time of the subiculum in adolescents: Implications for ultra‐high‐field magnetic resonance imaging

• Published in: Psychiatry and clinical neurosciences Vol. 73; no. 6; pp. 340 - 346
• Main Authors: Jeon, Sehyun, Hwang, Seok‐Il, Son, Young Don, Kim, Young‐Bo, Lee, Yu Jin, Kim, Seog Ju
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01.06.2019; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adolescent Development - physiology; Adolescents; delayed recall; Female; Hippocampus; Hippocampus - diagnostic imaging; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - instrumentation; Male; Memory; Mental Recall - physiology; Neuroimaging - instrumentation; NMR; Nuclear magnetic resonance; Pattern Recognition, Visual - physiology; Recognition, Psychology - physiology; Spatial memory; Subiculum; Teenagers; ultra‐high‐field; delayed recall; adolescent; subiculum; hippocampus; ultra-high-field
• ISSN: 1323-1316; 1440-1819; 1440-1819
• DOI: 10.1111/pcn.12843

Aim The aim of this study was to assess neuropsychological correlations with the T2* relaxation time (T2*‐RT) of hippocampal subregions in adolescents using ultra‐high‐field (UHF) 7.0‐T magnetic resonance imaging (MRI). Methods We assessed the T2*‐RT of hippocampal subregions in 31 healthy 11th‐ or 12th‐grade high school students using an UHF 7.0‐T MRI system. T2*‐RT of the cornu ammonis (CA) 1, CA2, CA3, and CA4 subregions and the subiculum were calculated for both the left and right hippocampus. Seven subtests of the Cambridge Neuropsychological Test Automated Battery were administered to the subjects to assess visuospatial memory. Results Poor performances in delayed recall in the pattern‐recognition test were significantly correlated with longer T2*‐RT in the bilateral subiculum (right, r = −0.480, P = 0.006; left, r = −0.648, P < 0.001) and the left CA2 (r = −0.480, P = 0.006). Conclusion This study showed that longer T2*‐RT in the subiculum were associated with poorer performances in delayed recall in the visual memory tasks. This finding suggests that the subiculum might play a predominant role in delayed recall in adolescents.