A Concise Route to Valacyclovir Hydrochloride
An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)‐2‐azido‐3‐methylbutanoic acid followed by reduction (Scheme 2).
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| Published in | Helvetica chimica acta Vol. 94; no. 4; pp. 592 - 596 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Zürich
WILEY-VCH Verlag
01.04.2011
WILEY‐VCH Verlag Wiley |
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| Abstract | An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)‐2‐azido‐3‐methylbutanoic acid followed by reduction (Scheme 2). |
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| AbstractList | An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)‐2‐azido‐3‐methylbutanoic acid followed by reduction (Scheme 2). Abstract An efficient and concise synthesis of valacyclovir hydrochloride ( 4 ), which is a prodrug of acyclovir ( 3 ) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2 S )‐2‐azido‐3‐methylbutanoic acid followed by reduction ( Scheme 2 ). |
| Author | Vedantham, Ravindra Anand Ramasamy, Vijaya Vetukuri, Prasada Raju V. N. K. V. Thippannachar Mathad, Vijayavitthal Reddy Padi, Pratap |
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| Cites_doi | 10.1016/j.bmcl.2008.06.069 10.1021/ol701581g 10.1086/424519 10.1001/jama.296.8.964 10.1001/jama.283.6.791 10.1097/00007435-198501000-00007 10.1358/dof.1993.018.07.218439 10.1086/343739 10.1056/NEJM199911043411904 10.1086/342966 10.1177/095632029200300305 |
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| SubjectTerms | Acyclovir Antiviral activity Azide Chemistry Chemistry, Multidisciplinary Physical Sciences Prodrugs Science & Technology Valacyclovir hydrochloride Valine |
| Title | A Concise Route to Valacyclovir Hydrochloride |
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