A Concise Route to Valacyclovir Hydrochloride

An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)‐2‐azido‐3‐methylbutanoic acid followed by reduction (Scheme 2).

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Bibliographic Details
Published inHelvetica chimica acta Vol. 94; no. 4; pp. 592 - 596
Main Authors Vetukuri, Prasada Raju V. N. K. V., Vedantham, Ravindra, Thippannachar Mathad, Vijayavitthal, Reddy Padi, Pratap, Anand Ramasamy, Vijaya
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.04.2011
WILEY‐VCH Verlag
Wiley
Subjects
Acyclovir
Antiviral activity
Azide
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Prodrugs
Science & Technology
Valacyclovir hydrochloride
Valine
HERPES-SIMPLEX-VIRUS
ACYCLOVIR
INFECTION
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Summary:An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)‐2‐azido‐3‐methylbutanoic acid followed by reduction (Scheme 2).
Bibliography:ArticleID:HLCA201000303
ark:/67375/WNG-JW03V5NK-6
istex:FE4917D0E56477D6AD9B30FA16A1CDA7AE1ADAFA
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201000303