Bionanocomposites comprising mesoporous metal organic framework (ZIF-8) phytofabricated with Allium sativum as alternative nanomaterials to combat antimicrobial drug resistance

• Published in: Bioprocess and biosystems engineering Vol. 47; no. 8; pp. 1335 - 1344
• Main Authors: Rehman, Suriya, Albhishiri, Ghadi, Alsalem, Zainab, AlJameel, Suhailah S., Al-Qaaneh, Ayman, Shah, Aarif Hussain, Akhtar, Sultan, Hameed, Saif, Jermy, B. Rabindran
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2024; Springer Nature B.V
• Subjects: Allium sativum; Antifungal activity; Antiinfectives and antibacterials; Antimicrobial agents; Bacteria; Biological activity; Biotechnology; Candida; Chemistry; Chemistry and Materials Science; Drug resistance; Environmental Engineering/Biotechnology; Food Science; Fourier transforms; Fungicides; Garlic; Impact resistance; Industrial and Production Engineering; Industrial Chemistry/Chemical Engineering; Infrared spectroscopy; Metal-organic frameworks; Nanocomposites; Nanomaterials; Nanoparticles; Nanotechnology; Research Paper; Spectrum analysis; Transmission electron microscopy; X-ray diffraction; X-ray spectroscopy; Bacteria; Mesoporous metal organic framework; Green nanotechnology; A. sativum; Candida
• ISSN: 1615-7591; 1615-7605; 1615-7605
• DOI: 10.1007/s00449-024-03027-y

Green nanotechnology is one of the most expanding fields that provides numerous novel nanoparticle drug formulations with enhanced bioactivity performance. This study aims to synthesize mesoporous metal organic framework (ZIF-8) phytofabricated with the herb Allium sativum (As) as an indicator system for its antibacterial and antifungal impact. The successful synthesis of ZIF-8 as nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and scanning coupled with energy-dispersive X-ray spectroscopy and transmission electron microscopy (SEM–EDX and TEM) that showed the textural retainment of ZIF-8 on composite formation with A. sativum . The nanocomposite, A. sativum extract, and ZIF-8 were subjected to antimicrobial assays against Shigella flexneri , Candida albicans , and Candida parapsilosis . The comparative results indicated the potential action of nanocomposite against the bacteria and both the Candida sps ; however, the antifungal action against the C andida sps was more effective than the bacterium S. flexneri . The findings suggest that plants, being an important component of ecosystems, could be further explored for the novel drug discovery using green nanotechnology to enhance their impact on the drug-resistant pathogens.