SiO2/SiC Nanowire Surfaces as a Candidate Biomaterial for Bone Regeneration

Tissue engineering (TE) and nanomedicine require devices with hydrophilic surfaces to better interact with the biological environment. This work presents a study on the wettability of cubic silicon-carbide-based (SiC) surfaces. We developed four cubic silicon-carbide-based epitaxial layers and three...

Full description

Saved in:
Bibliographic Details
Published inCrystals (Basel) Vol. 13; no. 8; p. 1280
Main Authors Ghezzi, Benedetta, Attolini, Giovanni, Bosi, Matteo, Negri, Marco, Lagonegro, Paola, Rotonda, Pasquale M., Cornelissen, Christine, Macaluso, Guido Maria, Lumetti, Simone
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
Subjects
Biocompatibility
Biomedical engineering
Biomedical materials
Biosensors
bone regeneration
Epitaxial layers
Fibroblasts
Hydrogen
Hydrogen plasma
hydrogen plasma treatment
hydrophilic surfaces
Materials selection
Morphology
Nanowires
Plasma
Regeneration (physiology)
Silicon carbide
Silicon dioxide
Substrates
Temperature
Tissue engineering
Topography
Transplants & implants
Wettability
Online AccessGet full text

Cover

More Information
Summary:Tissue engineering (TE) and nanomedicine require devices with hydrophilic surfaces to better interact with the biological environment. This work presents a study on the wettability of cubic silicon-carbide-based (SiC) surfaces. We developed four cubic silicon-carbide-based epitaxial layers and three nanowire (NW) substrates. Sample morphologies were analyzed, and their wettabilities were quantified before and after a hydrogen plasma treatment to remove impurities due to growth residues and enhance hydrophilicity. Moreover, sample biocompatibility has been assessed with regard to L929 cells. Our results showed that core–shell nanowires (SiO2/SiC NWs), with and without hydrogen plasma treatment, are the most suitable candidate material for biological applications due to their high wettability that is not influenced by specific treatments. Biological tests underlined the non-toxicity of the developed biomaterials with regard to murine fibroblasts, and the proliferation assay highlighted the efficacy of all the surfaces with regard to murine osteoblasts. In conclusion, SiO2/SiC NWs offer a suitable substrate to develop platforms and membranes useful for biomedical applications in tissue engineering due to their peculiar characteristics.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst13081280