Personalized Numerical Cardiovascular Model with Weight Growth for Evaluating Pediatric Left Ventricular Assist Devices: Derivation from an Experimental Mock Circulatory Loop

• Published in: Annals of biomedical engineering Vol. 52; no. 2; pp. 302 - 317
• Main Authors: Tran, Phong, Tedesco, Victor, Kiang, Simon, Karnik, Shweta, Nguyen, David, Frazier, O. H., Fraser, Katharine H., Wang, Yaxin
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2024; Springer Nature B.V
• Subjects: Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Child; Classical Mechanics; Congestive heart failure; Heart Failure; Heart Transplantation; Heart-Assist Devices; Hemodynamics; Humans; Impellers; Mathematical models; Models, Cardiovascular; Numerical models; Original Article; Patients; Pediatrics; Physiology; Tissue Donors; Ventricle; Ventricular assist devices; Left ventricular assist device; Heart failure; Hemodynamics; Computational modeling
• ISSN: 0090-6964; 1573-9686; 1573-9686
• DOI: 10.1007/s10439-023-03376-x

Pediatric patients with heart failure have limited treatment options because of a shortage of donor hearts and compatible left ventricular assist devices (LVADs). To address this issue, our group is developing an implantable pediatric LVAD for patients weighing 5–20 kg, capable of accommodating different physiological hemodynamic conditions as patients grow. To evaluate LVAD prototypes across a wide range of conditions, we developed a numerical cardiovascular model, using data from a mock circulatory loop (MCL) and patient-specific elastance functions. The numerical MCL was validated against experimental MCL results, showing good agreement, with differences ranging from 0 to 11%. The numerical model was also tested under left heart failure conditions and showed a worst-case difference of 16%. In an MCL study with a pediatric LVAD, a pediatric dataset was obtained from the experimental MCL and used to tune the numerical MCL. Then, the numerical model simulated LVAD flow by using an HQ curve obtained from the LVAD’s impeller. When the numerical MCL was validated against the experimental MCL, hemodynamic differences ranged between 0 and 9%. These findings suggest that the numerical model can replicate various physiological conditions and impeller designs, indicating its potential as a tool for developing and optimizing pediatric LVADs.