Inotropic response of the myocardium in rats with postinfarction cardiosclerosis exposed to extrasystolic treatment

• Published in: Bulletin of experimental biology and medicine Vol. 139; no. 6; pp. 647 - 650
• Main Authors: Kondrat'eva, D S, Afanas'ev, S A, Falaleeva, L P, Shakhov, V P
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.06.2005
• Subjects: Animals; Anti-Arrhythmia Agents - pharmacology; Calcium - metabolism; Electric Stimulation; Heart Ventricles - metabolism; Isometric Contraction - drug effects; Male; Myocardial Contraction - drug effects; Myocardial Ischemia - etiology; Myocardial Ischemia - metabolism; Myocardial Ischemia - physiopathology; Myocardium - metabolism; Myocytes, Cardiac - metabolism; Papillary Muscles - physiology; Perfusion; Rats; Rats, Wistar; Sarcoplasmic Reticulum - metabolism; Systole
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-005-0367-2

The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions in the remodeled myocardium far surpassed the control. However, the amplitude of postextrasystolic contraction did not surpass that in normal contraction-relaxation cycle. Our results suggest that the ability of the sarcoplasmic reticulum in cardiomyocytes to accumulate Ca2+ is impaired during postinfarction remodeling.