A systematic review and meta-analysis on the diagnostic utility of ultrasound for clavicle fractures

• Published in: Skeletal radiology Vol. 53; no. 2; pp. 307 - 318
• Main Authors: Hassankhani, Amir, Amoukhteh, Melika, Jannatdoust, Payam, Valizadeh, Parya, Gholamrezanezhad, Ali
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2024; Springer Nature B.V
• Subjects: Clavicle; Data analysis; Fractures; Heterogeneity; Image resolution; Imaging; Likelihood ratio; Medical imaging; Medicine; Medicine & Public Health; Meta-analysis; Nuclear Medicine; Orthopedics; Pathology; Pediatrics; Radiology; Scientific Article; Subgroups; Systematic review; Ultrasonic imaging; Ultrasound; Ultrasound; Diagnosis; Clavicle fracture
• ISSN: 0364-2348; 1432-2161
• DOI: 10.1007/s00256-023-04396-3

Background Ultrasound’s real-time, high-resolution imaging, and accessibility at the point of care make it a valuable tool for diagnosing clavicle fractures, with growing evidence supporting its diagnostic accuracy compared to other imaging modalities. Objective To assess the diagnostic utility of ultrasound in detecting clavicle fractures. Methods A systematic review and meta-analysis were conducted by performing a comprehensive literature search in PubMed, Scopus, Web of Science, and Embase databases up to March 10, 2023, following established guidelines. Eligible studies that reported outcomes of interest were included, relevant data elements were extracted, and data analysis was performed using STATA software version 17.0. Results Meta-analysis of seven included studies showed high-pooled sensitivity (0.94) and specificity (0.98) values for ultrasonography in diagnosing clavicle fractures, with low to moderate heterogeneity for sensitivity and high heterogeneity for specificity. Meta-regression and subgroup analyses revealed that pediatric studies had higher sensitivity but significantly lower specificity ( P =0.01) compared to mixed or adult studies. Additional subgroup analysis in the pediatric group indicated decreased heterogeneity for specificity. Fagan plot analysis demonstrated favorable post-test probabilities for both positive and negative results across varying pre-test probabilities. Additionally, the likelihood ratio scatter matrix showed moderate to high test performance for both exclusion and confirmation purposes. Conclusion The current literature supports ultrasound as a reliable imaging modality for detecting clavicle fractures. It offers accurate diagnosis without exposing patients, especially children, to radiation.