Comment on: “Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65”

• Published in: Journal of clinical anesthesia Vol. 81; p. 110891
• Main Author: Mandel, Jeff E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2022; Elsevier Limited
• Subjects: Age; Hypotension; Infusion pumps
• ISSN: 0952-8180; 1873-4529
• DOI: 10.1016/j.jclinane.2022.110891

[...]slow delivery rates, whether performed by an infusion pump and documented as an infusion rate, or as a cumulative amount delivered over that period but documented as a single bolus, would escape notice in this analysis. [...]there is considerable variability in the quantity of propofol required to achieve the endpoint of loss of airway tone, variability that cannot be predicted with any certainty. [...]a slow administration of propofol until the clinical objective is attained will yield a smooth transition to anesthetic induction devoid of problematic hypotension.