Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions

Receptor-interacting protein kinase 1 (RIPK1) plays a crucial role in controlling inflammation and cell death. Its function is tightly controlled through post-translational modifications, enabling its dynamic switch between promoting cell survival and triggering cell death. Phosphorylation of RIPK1...

Full description

Saved in:
Bibliographic Details
Published inBiomedicines Vol. 12; no. 7; p. 1525
Main Authors Du, Jingchun, Wang, Zhigao
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 09.07.2024
Subjects
Apoptosis
Cell death
Cell survival
Dephosphorylation
Inflammation
Inflammatory diseases
kinase
Kinases
Ligands
Mutation
Pathogens
Phosphorylation
Post-translation
Proteins
RIPK1
Therapeutic applications
Tumor necrosis factor-TNF
kinase
therapeutics
cell death
inflammation
dephosphorylation
apoptosis
RIPK1
phosphatase
phosphorylation
necroptosis
Online AccessGet full text

Cover

More Information
Summary:Receptor-interacting protein kinase 1 (RIPK1) plays a crucial role in controlling inflammation and cell death. Its function is tightly controlled through post-translational modifications, enabling its dynamic switch between promoting cell survival and triggering cell death. Phosphorylation of RIPK1 at various sites serves as a critical mechanism for regulating its activity, exerting either activating or inhibitory effects. Perturbations in RIPK1 phosphorylation status have profound implications for the development of severe inflammatory diseases in humans. This review explores the intricate regulation of RIPK1 phosphorylation and dephosphorylation and highlights the potential of targeting RIPK1 phosphorylation as a promising therapeutic strategy for mitigating human diseases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12071525