Interaction between Habitual Green Tea and Coffee Consumption and ACTN3 Genotype in Association with Skeletal Muscle Mass and Strength in Middle-Aged and Older Adults
Background Recent studies have suggested the potential benefits of habitual coffee and green tea consumption on skeletal muscle health. However, it remains unclear whether these benefits are modified by genetic factors, particularly the alpha-actinin-3 (ACTN3) genotype, which is associated with the...
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Published in | The Journal of Frailty & Aging Vol. 13; no. 3; pp. 267 - 275 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
2024
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Recent studies have suggested the potential benefits of habitual coffee and green tea consumption on skeletal muscle health. However, it remains unclear whether these benefits are modified by genetic factors, particularly the alpha-actinin-3
(ACTN3)
genotype, which is associated with the skeletal muscle phenotype. This study aimed to investigate the interaction between habitual coffee or green tea consumption and the
ACTN3
genotype in association with skeletal muscle mass (SMM) and strength.
Methods
This cross-sectional study was conducted on 1,023 Japanese middle-aged and older adults (619 females, aged 45–74 years) living in the community. SMM was gauged using a bioelectrical impedance spectroscopy device, and handgrip strength (HGS) was used to measure muscle strength. The
ACTN3
genotype (RR, RX, and XX) was determined from blood samples. Sex-specific linear regression models were used to analyze the interactions between coffee or green tea consumption and the
ACTN3
genotype in association with SMM and HGS.
Results
In females, a significant interaction was observed between green tea consumption and the
ACTN3
genotype in association with HGS (P interaction < 0.05). Furthermore, stratified analysis revealed a positive association between green tea consumption and HGS, specifically in females with the
ACTN3
XX genotype (P trend < 0.05). In males, no significant interactions were observed between coffee or green tea consumption and the
ACTN3
genotype in association with SMM or HGS (P interaction > 0.05).
Conclusion
Our findings suggest that the skeletal muscle strength benefits associated with habitual green tea consumption may be contingent upon sex and the
ACTN3
genotype. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2260-1341 2273-4309 |
DOI: | 10.14283/jfa.2024.3 |