Evaluation of correlation between Diopsys® NOVA™ fixed-luminance flicker ERG and Diagnosys® Espion 2™ flicker ERG parameters

• Published in: Documenta ophthalmologica Vol. 146; no. 3; pp. 257 - 266
• Main Authors: Regenold, Jonathan, Doan, Hien Luong, Ghoraba, Hashem, Khojasteh, Hassan, Jaclyn Hwang, Jaclyn Joyce, Yavari, Negin, Akhavanrezayat, Amir, Than, Ngoc Trong Tuong, Le, Anthony Huy Dinh, Halim, Muhammad Sohail, Nguyen, Quan Dong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2023; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Electrophysiology; Electroretinograms; Electroretinography - methods; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Original Research Article; Patients; Photic Stimulation; Retina; Statistical analysis; Young Adult; Fixed luminance; Full-field electroretinography; Diopsys; Diagnosys; Flicker electroretinography
• ISSN: 0012-4486; 1573-2622
• DOI: 10.1007/s10633-023-09934-x

Purpose Diopsys® NOVA™ is a novel full-field electroretinography (ffERG) device that can make rapid measurements of retinal electrophysiologic function. Diagnosys® Espion 2™ is a clinical gold-standard ERG device. This study aimed to investigate whether light-adapted Diopsys® NOVA™ fixed-luminance flicker ffERG  magnitude and  implicit time (converted from phase ) measurements correlate with light-adapted Diagnosys® Espion 2™ flicker ffERG amplitude and implicit time measurements, respectively. Methods Twelve patients (22 eyes) with various retinal and uveitic diseases underwent light-adapted Diagnosys® Espion 2™ and Diopsys® NOVA™ fixed-luminance flicker testing. Diopsys®  magnitude and implicit time (converted from phase ) measurements were compared to Diagnosys®  amplitude and implicit time  measurements, and a Pearson correlation was used to evaluate any existing correlation. Groups were also compared using generalized estimating equations. Bland–Altman plots were utilized to determine agreement between the comparison groups. Results Age of patients ranged from 14 to 87 years. 58% ( n  = 7/12) of patients were female. A significant, positive correlation ( r  = 0.880, P  < 0.001) was observed between  magnitude  (Diopsys®) and  amplitude  (Diagnosys®) measurements. Amplitude increases by 6.69 µV for each 1 µV increase in Magnitude ( p -value < 0.001). A statistically significant, strong positive correlation was observed between Diopsys® implicit time measurements (converted from phase ) and Diagnosys® implicit time measurements ( r  = 0.814, p -value < 0.001). For each 1 ms increase in Diopsys® implicit time , Diagnosys® implicit time increases by 1.13 ms ( p -value < 0.001). Conclusions There is a statistically significant positive correlation between light-adapted Diopsys® NOVA™ fixed-luminance flicker amplitude  and Diagnosys® flicker  magnitude values. Additionally, there is a statistically significant positive correlation between Diopsys® NOVA™ fixed-luminance flicker implicit time (converted from phase ) and Diagnosys® flicker  implicit time values. These results imply that the Diopsys® NOVA™ module, which utilizes the nonstandard shortened International Society for Clinical Electrophysiology of Vision (ISCEV) ERG protocol, can produce reliable light-adapted flicker ffERG measurements.