Increased inferior vena cava wall thickness as a sign of extensive venous inflammation in Behçet’s Disease

• Published in: Clinical rheumatology Vol. 43; no. 4; pp. 1355 - 1362
• Main Authors: Ağaçkıran, Seda Kutluğ, Sünbül, Murat, Doğan, Zekeriya, Direskeneli, Haner, Alibaz-Oner, Fatma
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2024; Springer Nature B.V
• Subjects: Behcet's syndrome; Doppler effect; Echocardiography; Femur; Inflammation; Medicine; Medicine & Public Health; Original Article; Rheumatology; Vein & artery diseases; Veins; Veins & arteries; Diagnostic imaging; Echocardiography; Behçet’s disease; Inferior vena cava
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-024-06911-w

Introduction/objectives Behçet’s disease (BD) affects both arterial and venous vessels. We have previously shown that common femoral vein wall thickness (WT) is increased in BD and can be used as a diagnostic test. However, there is limited data assessing large veins. Therefore, this study seeks to assess inferior vena cava wall thickness (IVC) by transthoracic echocardiography (TTE) in BD compared to healthy controls (HC). Methods Age- and gender-matched 70 BD patients and 51 HC were included. IVC wall thickness and common femoral vein WT were measured by TTE and Doppler ultrasonography, respectively. All examinations were performed on the same day as the clinical assessment. Results The mean IVC wall thickness of BD patients was significantly higher than HC (2.9 mm (0.3) vs 2.6 mm (0.3), p  < 0.001). Patients with mucocutaneous involvement (2.8 mm (0.3)) and major organ involvement (2.9 mm (0.3)) had significantly thicker walls compared to HC ( p  = 0.003, p  < 0.001, respectively). IVC wall thickness was higher in patients with vascular involvement compared to those with nonvascular major organ involvement (3.1 mm (0.3) vs 2.8 mm (0.2), p  = 0.04). There was a moderate correlation between IVC and common femoral vein WT ( r  = 0.49 for the right, r  = 0.43 for the left, p  = 0.01 for both). Conclusion This study shows that venous wall inflammation is not limited to lower extremity veins and is also present in IVC walls of BD patients regardless of IVC involvement. Vascular wall inflammation is probably a widespread vascular event of all venous walls in BD. Key Points • Venous wall inflammation is not limited to lower extremity veins and is present also in IVC wall in Behçet’s disease. • Extensive venous wall inflammation in Behçet’s disease includes large venous structures despite not being clinically involved.