Therapeutic Potential of Aloe vera and Aloe vera–Conjugated Silver Nanoparticles on Mice Exposed to Hexavalent Chromium

• Published in: Biological trace element research Vol. 202; no. 12; pp. 5580 - 5595
• Main Authors: Nauroze, Tooba, Ali, Shaukat, Andleeb, Shagufta, Ara, Chaman, Liaqat, Iqra, Mushtaq, Hina, Mumtaz, Samaira, Kanwal, Lubna, Abbas, Afshan Syed, Mumtaz, Shumaila, Farooq, Muhammad Adeel, Khan, Istaqlal Hussain
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2024; Springer Nature B.V
• Subjects: Alanine; Alanine transaminase; Alkaline phosphatase; Aloe; Aloe vera; Aspartate aminotransferase; Biochemistry; Biomedical and Life Sciences; Biotechnology; Blood; Blood levels; Chromium; Creatinine; Exposure; Glomerulus; Heavy metals; Hepatocytes; Hepatotoxicity; Hexavalent chromium; Histopathology; Life Sciences; Liver; Malondialdehyde; Nanoparticles; Necrosis; Nutrition; Oncology; Oxidative stress; Phosphatase; Proteins; Serum; Silver; Transaminases; Hexavalent chromium; Micrometry; Histopathology; Hepatocytes; Necrosis
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-024-04105-8

Hexavalent chromium (Cr (VI)) is a hazardous heavy metal that induces hepatotoxicity and nephrotoxicity. Thus, this study was planned to explore the ameliorating capacity of Aloe vera leaf gel extract (AV) and their conjugated silver nanoparticles (AVNP) against Cr (VI) induced hepatotoxicity and renal toxicity. The organ indices, level of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, malondialdehyde, total protein, and creatinine in blood serum were measured. The histopathological and micrometric analysis of the hepatic and renal tissue sections were studied. The hepatosomatic index was raised significantly (0.098 ± 0.13 g) in Cr treated group. The blood serum level of AST (484 ± 10.7 U/L), ALT (163 ± 5.5 U/L), ALP (336.7 ± 9.5 U/L), MDA (642.3 ± 28.3 U/L), and creatinine (4.0 ± 0.1 mg/dL) were increased significantly, whereas total protein level was declined (2.8 ± 0.3 g/dL) significantly in Cr exposed group. In the histopathological study, necrosis, disturbed hepatic cords, impaired glomeruli, and Bowman’s capsule were noted. Micrometric data from the liver and kidney revealed a significant surge in the size of hepatocytes and their nuclei (1188.2 ± 467.7 µ 2 and 456.5 ± 205.6 µ 2 ) and CSA of glomeruli and Bowman’s capsule (9051.8 ± 249.8 µ 2 and 11,835.5 ± 336.7 µ 2 ) in Cr (VI) exposed group, whereas the brush border (10.2 ± 4.0 µ) size declined significantly. The administration of AV and AVNP reduced the oxidative stress induced by Cr (VI).