Insight into the role of copper-based materials against the coronaviruses MHV-3, a model for SARS-CoV-2, during the COVID-19 pandemic

Coating high-touch surfaces with inorganic agents, such as metals, appears to be a promising long-term disinfection strategy. However, there is a lack of studies exploring the effectiveness of copper-based products against viruses. In this study, we evaluated the cytotoxicity and virucidal effective...

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Published inBiometals Vol. 37; no. 4; pp. 923 - 941
Main Authors Jacinto, Gislaine S., Dias, Leonardo F. G., Tsukamoto, Junko, Lisboa-Filho, Paulo N., Souza, Marina T., de Moraes, Ana Paula, Arns, Clarice W.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.08.2024
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Cell Biology
Copper
Copper oxides
Coronaviruses
COVID-19
Cytotoxicity
Disinfection
Effectiveness
Heavy metals
Hepatitis
Life Sciences
Low concentrations
Medicine/Public Health
Microbiology
Nanoparticles
Pandemics
Pharmacology/Toxicology
Plant Physiology
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viruses
Self-disinfection
Virucidal activity
SARS-CoV-2
Copper
MHV-3
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Summary:Coating high-touch surfaces with inorganic agents, such as metals, appears to be a promising long-term disinfection strategy. However, there is a lack of studies exploring the effectiveness of copper-based products against viruses. In this study, we evaluated the cytotoxicity and virucidal effectiveness of products and materials containing copper against mouse hepatitis virus (MHV-3), a surrogate model for SARS-CoV-2. The results demonstrate that pure CuO and Cu possess activity against the enveloped virus at very low concentrations, ranging from 0.001 to 0.1% (w/v). A greater virucidal efficacy of CuO was found for nanoparticles, which showed activity even against viruses that are more resistant to disinfection such as feline calicivirus (FCV). Most of the evaluated products, with concentrations of Cu or CuO between 0.003 and 15% (w/v), were effective against MHV-3. Cryomicroscopy images of an MHV-3 sample exposed to a CuO-containing surface showed extensive damage to the viral capsid, presumably due to the direct or indirect action of copper ions.
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ISSN:0966-0844
1572-8773
1572-8773
DOI:10.1007/s10534-024-00585-2