Quantitative and Radiological Assessment of Post-cardiac-Arrest Comatose Patients with Diffusion-Weighted Magnetic Resonance Imaging

• Published in: Neurocritical care Vol. 42; no. 2; pp. 541 - 550
• Main Authors: Van Roy, Sam, Hsu, Liangge, Ho, Joseph, Scirica, Benjamin M., Fischer, David, Snider, Samuel B., Lee, Jong Woo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2025; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Cardiac arrest; Coma; Coma - diagnostic imaging; Coma - etiology; Coma - pathology; Critical Care Medicine; Datasets; Diffusion Magnetic Resonance Imaging - methods; Diffusion Magnetic Resonance Imaging - standards; Female; Heart Arrest - complications; Humans; Hypoxia, Brain - diagnosis; Hypoxia, Brain - diagnostic imaging; Hypoxia, Brain - etiology; Hypoxia, Brain - pathology; Intensive; Internal Medicine; Magnetic resonance imaging; Male; Medical records; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neurosurgery; Original Work; Patients; Radiology; Regression analysis; Retrospective Studies; Review boards; Statistical analysis; Anoxic brain injury; Coma; Diffusion-weighted imaging; Radiological assessment; Neurological recovery; Cardiac arrest
• ISSN: 1541-6933; 1556-0961; 1556-0961
• DOI: 10.1007/s12028-024-02087-y

Background Although magnetic resonance imaging, particularly diffusion-weighted imaging, has increasingly been used as part of a multimodal approach to prognostication in patients who are comatose after cardiac arrest, the performance of quantitative analysis of apparent diffusion coefficient (ADC) maps, as compared to standard radiologist impression, has not been well characterized. This retrospective study evaluated quantitative ADC analysis to the identification of anoxic brain injury by diffusion abnormalities on standard clinical magnetic resonance imaging reports. Methods The cohort included 204 previously described comatose patients after cardiac arrest. Clinical outcome was assessed by (1) 3–6 month post-cardiac-arrest cerebral performance category and (2) coma recovery to following commands. Radiological evaluation was obtained from clinical reports and characterized as diffuse, cortex only, deep gray matter structures only, or no anoxic injury. Quantitative analyses of ADC maps were obtained in specific regions of interest (ROIs), whole cortex, and whole brain. A subgroup analysis of 172 was performed after eliminating images with artifacts and preexisting lesions. Results Radiological assessment outperformed quantitative assessment over all evaluated regions (area under the curve [AUC] 0.80 for radiological interpretation and 0.70 for the occipital region, the best performing ROI, p  = 0.011); agreement was substantial for all regions. Radiological assessment still outperformed quantitative analysis in the subgroup analysis, though by smaller margins and with substantial to near-perfect agreement. When assessing for coma recovery only, the difference was no longer significant (AUC 0.83 vs. 0.81 for the occipital region, p  = 0.70). Conclusions Although quantitative analysis eliminates interrater differences in the interpretation of abnormal diffusion imaging and avoids bias from other prediction modalities, clinical radiologist interpretation has a higher predictive value for outcome. Agreement between radiological and quantitative analysis improved when using high-quality scans and when assessing for coma recovery using following commands. Quantitative assessment may thus be more subject to variability in both clinical management and scan quality than radiological assessment.