Periprocedural Changes of Serum Biomarkers in Predicting Complications Following Bariatric Surgery for Obesity: Systematic Review and Meta-analysis

Bariatric surgery is an effective treatment for severe obesity, but complications and peri-operative monitoring are important considerations. We conducted a comprehensive review of studies assessing pre-operative biomarkers and complications in patients undergoing bariatric surgery. A total of 14 st...

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Bibliographic Details
Published inObesity surgery Vol. 34; no. 6; pp. 2198 - 2215
Main Authors AziziKia, Hani, Shojaei, Shayan, Mousavi, Asma, Salabat, Dorsa, Shaker, Farhad, Dolama, Reza Hosseini, Radkhah, Hanieh, Alilou, Sanam
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2024
Springer Nature B.V
Subjects
Bariatric Surgery - adverse effects
Biomarkers
Biomarkers - blood
Blood
Body mass index
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Cohort analysis
Diabetes
Female
Gastrointestinal surgery
Heart surgery
Hematology
Humans
Keywords
Leukocytes
Lymphocytes
Medical prognosis
Medicine
Medicine & Public Health
Meta-analysis
Neutrophils
Obesity
Obesity, Morbid - blood
Obesity, Morbid - complications
Obesity, Morbid - surgery
Postoperative Complications - blood
Postoperative Complications - etiology
Predictive Value of Tests
Proteins
Review
Surgery
Surgical anastomosis
Systematic review
Thromboembolism
Thrombosis
Weight control
Inflammatory biomarkers
CBC biomarkers
Complications
Bariatric surgery
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Summary:Bariatric surgery is an effective treatment for severe obesity, but complications and peri-operative monitoring are important considerations. We conducted a comprehensive review of studies assessing pre-operative biomarkers and complications in patients undergoing bariatric surgery. A total of 14 studies were included. Gastric leak, infections, bleeding, obstruction or stenosis, hypoglycemia, and hypoalbuminemia were the most common complications observed. Our analysis showed a significant association between lower pre-operative albumin levels and complications (SMD [95%CI] =  − 0.21 [− 0.38; − 0.04]). However, other biomarkers did not have a significant impact on complication occurrence. Changes in C-reactive protein, neutrophil–lymphocyte ratio, and white blood cell levels were observed in certain peri-operative time points and complication subgroups. These findings suggest the potential use of pre-operative biomarkers and peri-operative changes of biomarker’s levels for predicting complications. Graphical Abstract
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ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-024-07234-0