Effects of vitamin supply on spontaneous and chemically induced mutagenesis in human cells

Chromosome aberrations in donor peripheral blood lymphocyte culture were evaluated before, 14 and 30 days after treatment with a vitamin/mineral complex. Treatment with the complex had no effect on spontaneous level of aberrant cells. The number of chromosome aberrations induced by dioxidine or cadm...

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Published inBulletin of experimental biology and medicine Vol. 139; no. 2; pp. 230 - 234
Main Authors Sidneva, E S, Katosova, L D, Platonova, V I, Beketova, N A, Kodentsova, V M, Chebotarev, A N, Durnev, A D, Bochkov, N P
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.02.2005
Subjects
Adult
Cadmium Chloride - toxicity
Cells, Cultured
Chromosome Aberrations - drug effects
Female
Humans
Lymphocytes - cytology
Lymphocytes - drug effects
Male
Mutagenesis
Mutagens - toxicity
Quinoxalines - toxicity
Vitamins - administration & dosage
Vitamins - pharmacology
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Summary:Chromosome aberrations in donor peripheral blood lymphocyte culture were evaluated before, 14 and 30 days after treatment with a vitamin/mineral complex. Treatment with the complex had no effect on spontaneous level of aberrant cells. The number of chromosome aberrations induced by dioxidine or cadmium chloride in vitro at the G2 stage decreased on days 14 and 30 of treatment with the complex.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0256-8