Ghrelin and PYY3−36 in gastrectomized and vagotomized patients: relations with appetite, energy intake and resting energy expenditure

• Published in: European journal of clinical nutrition Vol. 64; no. 8; pp. 845 - 852
• Main Authors: Kamiji, M M, Troncon, L E A, Antunes-Rodrigues, J, Elias, L L K, de Castro, M, Oliveira, R B
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2010; Nature Publishing Group
• Subjects: 631/443; 631/443/319/333/1465; 631/45/776/198; 692/700/565/545; Appetite; Appetite loss; Biological and medical sciences; Body weight; Clinical Nutrition; Diet; Energy expenditure; Energy intake; Epidemiology; Fasting; Feeding. Feeding behavior; Food; Food intake; Fundamental and applied biological sciences. Psychology; Gastrectomy; Gastrointestinal surgery; Ghrelin; Hormones; Hunger; Ingestion; Internal Medicine; Laboratory testing; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; original-article; Peptides; Public Health; Ratings; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Vagotomy; Vertebrates: anatomy and physiology, studies on body, several organs or systems; ghrelin; appetite; gastrectomy; peptide YY; energy expenditure; Appetite; Human; Energy input; Metabolic diseases; Gastrectomy; Appetite stimulant; Treatment; Energetic cost; Ghrelin; Surgery; YY peptide
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2010.88

Background/Objectives: Reduced food intake, appetite loss and alteration of ghrelin and PYY 3−36 secretion have been suggested to have a function in the loss of body weight commonly observed after gastrectomy. The objective of this study was to investigate the circulating concentrations of ghrelin and PYY 3−36 and their relationships with food intake, appetite and resting energy expenditure (REE) after gastrectomy plus vagotomy. Subjects/Methods: Seven patients with total gastrectomy (TG), 14 with partial gastrectomy (PG) and 10 healthy controls were studied. Habitual food intake and REE was assessed; fasting and postprandial plasma total ghrelin, PYY 3−36 concentrations and appetite ratings were determined after ingestion of a liquid test meal. Results: Differently from PG and controls, fasting ghrelin correlated with REE, and a higher energy intake was observed in the TG group. Fasting plasma ghrelin concentrations were lower in TG compared with controls, and no ghrelin response to the meal was observed in either PG or TG. Fasting plasma PYY 3−36 concentrations were not different among the groups. There was an early and exaggerated postprandial rise in PYY 3−36 levels in both PG and TG groups, but not in controls. No effect of ghrelin or PYY 3−36 concentrations was observed on hunger, prospective consumption or fullness ratings. Conclusions: Total ghrelin and PYY 3−36 do not seem to be involved with appetite or energy intake regulation after gastrectomy plus vagotomy. Ghrelin secreted by sources other than stomach is likely to have a function in the long-term regulation of body weight after TG.