Dietary vitamin E supplementation lowers blood pressure in spontaneously hypertensive rats

• Published in: Molecular and cellular biochemistry Vol. 238; no. 1-2; pp. 111 - 117
• Main Authors: Vasdev, S, Gill, V, Parai, S, Longerich, L, Gadag, V
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.09.2002
• Subjects: Administration, Oral; Aldehydes; Aldehydes - analysis; Animals; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Blood Platelets - drug effects; Blood Platelets - metabolism; Blood pressure; Blood Pressure - drug effects; Body Weight - drug effects; Calcium - blood; Dietary Supplements; Drinking Behavior - drug effects; Eating - drug effects; Hypertension; Hypertension - drug therapy; Kidneys; Organ Size - drug effects; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rodents; Time Factors; Vitamin E; Vitamin E - administration & dosage; Vitamin E - pharmacology; Vitamin E - therapeutic use
• ISSN: 0300-8177; 1573-4919
• DOI: 10.1023/A:1019915306581

In spontaneously hypertensive rats (SHRs) excess endogenous aldehydes bind sulfhydryl groups of membrane proteins, altering membrane Ca2+ channels and increasing cytosolic free calcium and blood pressure. The thiol compound, N-acetyl cysteine, normalizes elevated blood pressure in SHRs by binding excess endogenous aldehydes. Vitamin E increases tissue glutathione levels--a storage form of cysteine. The aim of the present study was to investigate whether a dietary supplementation of vitamin E lowers blood pressure and prevents renal vascular changes by normalizing tissue aldehyde conjugates and cytosolic [Ca2+] in SHRs. Starting at 12 weeks of age, animals were divided into three groups of six animals each. Animals in the WKY-control group and SHR-control group were given a normal diet and the SHR-vitamin E group a diet supplemented with vitamin E (34 mg/ kg feed) for the next 9 weeks. After 9 weeks, systolic blood pressure, platelet [Ca2+]i, and liver, kidney and aortic aldehyde conjugates were significantly higher in SHR controls as compared to WKY controls and the SHR-vitamin E group. SHR-controls also showed smooth muscle cell hyperplasia in the small arteries and arterioles of the kidney. Dietary vitamin E supplementation in SHRs lowered the systolic blood pressure, cytosolic [Ca2+], tissue aldehyde conjugates and attenuated adverse renal vascular changes.