Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction

• Published in: Turkish journal of medical sciences Vol. 45; no. 1; pp. 148 - 152
• Main Authors: Mushtaq, Sobia, Ali, Tahir, Altaf, Farhana, Abdullah, Muhammad, Murtaza, Iram
• Format: Journal Article
• Language: English
• Published: Turkey 2015
• Subjects: Calpain; Case-Control Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Female; Humans; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - complications; Myocardial Infarction - metabolism; Oxidative Stress - physiology; Reactive Oxygen Species - blood; Superoxide Dismutase - blood
• ISSN: 1300-0144; 1303-6165
• DOI: 10.3906/sag-1308-25

Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction. A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was checked using western blotting. The serum level of ROS and the expression of calpain-1 were significantly higher while the activity of SOD was significantly lower in diabetic patients with myocardial infraction compared to normal individuals. These findings suggest a possible link between decreased antioxidant (SOD) and increased ROS levels as well as calpain-1 expression, supporting the role of oxidative stress-regulatory factors in diabetes and myocardial infraction.