The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children

Abstract We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and sev...

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Published inJournal of the Pediatric Infectious Diseases Society Vol. 12; no. 3; pp. 169 - 172
Main Authors Simpson, Brittany N, Mejía Sang, Miguel E, Collado Puello, Yonairy, Diaz Brockmans, Elvira J, Díaz Soto, María F, Rivera Defilló, Stephanie M, Taveras Cruz, Karla M, Santiago Pérez, Javier O, Husami, Ammar, Day, Melissa E, Pilipenko, Valentina, Mena, Rafael, Mota, Cesár, Hostetter, Margaret K, Muglia, Louis J, Schlaudecker, Elizabeth, Gonzalez del Rey, Javier, Martin, Lisa J, Prada, Carlos E
Format Journal Article
LanguageEnglish
Published US Oxford University Press 18.04.2023
Subjects
Child
Cohort Studies
Dengue - diagnosis
Dengue - epidemiology
Dominican Republic - epidemiology
Genomics
Humans
Severe Dengue
Dominican Republic
dengue fever
interferon
children
genomic risk factors
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Summary:Abstract We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation. We performed an observational cohort study to assess associations between genetic risk factors and dengue fever (DF) severity in children in the Dominican Republic. Significant risk of severe DF was associated with polymorphisms in the IFIH1gene.
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ISSN:2048-7207
2048-7207
DOI:10.1093/jpids/piac136