Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line

In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX...

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Bibliographic Details
Published inGeneral physiology and biophysics Vol. 36; no. 4; p. 481
Main Authors Macejova, Dana, Toporova, Lucia, Brtko, Julius
Format Journal Article
LanguageEnglish
Published Slovakia 01.10.2017
Subjects
Cell Nucleus - drug effects
Cell Nucleus - metabolism
Humans
MCF-7 Cells
Organotin Compounds - administration & dosage
Retinoid X Receptors - metabolism
Tretinoin - administration & dosage
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Summary:In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX proteins. Tributyltin bromide markedly decreased mRNA level of RXRalpha and RXRbeta. Significantly reduced levels of both RXRs proteins were observed after treatment with tributyltin chloride (TBT-Cl) but not after treatment with triphenyltin chloride (TPT-Cl) for RXRbeta protein. Both RXRalpha and RXRbeta protein levels decrease was found also by combination ATRA+TBT-Cl/TPT-Cl.
ISSN:0231-5882
DOI:10.4149/gpb_2017038