Shimalactones, neuritogenic polyketides from a marine-derived fungus Emericella variecolor GF10

Shimalactone B (2), a novel polyketide having bicyclo[4.2.0]octadiene and oxabicyclo[2.2.1]heptane units, was isolated as a minor constituent from a cultured marine-derived fungus of Emericella variecolor GF10. The chemical structure of 2 and the structural relationship between shimalactones A and B...

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Bibliographic Details
Published inHeterocycles Vol. 68; no. 1; pp. 111 - 123
Main Authors Wei, H, Itoh, T, Kotoku, N, Kobayashi, M
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ABSOLUTE-CONFIGURATIONS
SNF4435C
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Summary:Shimalactone B (2), a novel polyketide having bicyclo[4.2.0]octadiene and oxabicyclo[2.2.1]heptane units, was isolated as a minor constituent from a cultured marine-derived fungus of Emericella variecolor GF10. The chemical structure of 2 and the structural relationship between shimalactones A and B (2) were determined by detailed NMR and CD spectroscopic analyses and chemical derivatization. Shimalactones A and B (2) induced neuritogenesis against neuroblastoma Neuro 2A cells at 10,mu g/mL concentration.
ISSN:0385-5414
1881-0942
DOI:10.3987/com-05-10589