Rheumatoid course of humoral (vascular) rejection after heart allotransplantation

Analysis of planned endomyocardial biopsy specimens of heart allotransplants from 22 recipients revealed signs of humoral type rejection (slight, medium, and severe) presenting as fixation of IgG, IgM, and complement components (C3, C4d) in 61 of 63 sections. Permanent presence of rejection signs at...

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Published inBulletin of experimental biology and medicine Vol. 142; no. 3; pp. 363 - 366
Main Authors Beletskaya, L V, Kupriyanova, A G, Kormer, A Ya, Mironkov, B L, Kazakov, E N, Shumakov, V I
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.09.2006
Subjects
Adult
Biopsy
Capillaries - chemistry
Capillaries - immunology
Complement C3 - immunology
Complement C4b - immunology
Coronary Vessels - chemistry
Coronary Vessels - immunology
Female
Fluorescein-5-isothiocyanate
Fluorescent Antibody Technique, Direct
Fluorescent Dyes
Graft Rejection - immunology
Graft Rejection - pathology
Heart Transplantation - immunology
Heart Transplantation - pathology
Humans
Immunoglobulin G - immunology
Immunoglobulin M - immunology
Immunohistochemistry
Male
Myocardium - immunology
Peptide Fragments - immunology
Transplantation, Homologous
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Summary:Analysis of planned endomyocardial biopsy specimens of heart allotransplants from 22 recipients revealed signs of humoral type rejection (slight, medium, and severe) presenting as fixation of IgG, IgM, and complement components (C3, C4d) in 61 of 63 sections. Permanent presence of rejection signs attests to rheumatoid course of this process.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0367-x